Clin Infect Dis. 2004 Apr 15;38(8):e79-80. Epub 2004 Mar 26.

Nucleoside analogues and mitochondrial toxicity.

Source

Division of Antiviral Drug Products, Center for Drug Evaluation and Research, Food and Drug Administration, Rockville, Maryland 20857, USA. fleischerr@cder.fda.gov

Abstract

An evaluation of the US Food and Drug Administration's Adverse Event Reporting System identified that patients coinfected with human immunodeficiency virus and chronic hepatitis C virus who were treated with a regimen of ribavirin and didanosine, with or without stavudine, were at increased risk for events associated with mitochondrial toxicity, including fatal hepatic failure, peripheral neuropathy, pancreatitis, and symptomatic hyperlactatemia/lactic acidosis. In response, the US product labels for didanosine and ribavirin have been revised to caution clinicians against coadministration of these drugs.

PMID:: 15095236; [PubMed - indexed for MEDLINE]

Free full text

LinkOut - more resources

Full Text Sources

Other Literature Sources

Labome Researcher Resource - ExactAntigen/Labome

Medical

Molecular Biology Databases

Supplemental Content

Save items

Related citations in PubMed

High rate of didanosine-related mitochondrial toxicity in HIV/HCV-coinfected patients receiving ribavirin. [Antivir Ther. 2004]
High rate of didanosine-related mitochondrial toxicity in HIV/HCV-coinfected patients receiving ribavirin.
Moreno A, Quereda C, Moreno L, Perez-Elías MJ, Muriel A, Casado JL, Antela A, Dronda F, Navas E, Bárcena R, et al. Antivir Ther. 2004 Feb; 9(1):133-8.
Fatal lactic acidosis and pancreatitis associated with ribavirin and didanosine therapy. [AIDS Read. 2003]
Fatal lactic acidosis and pancreatitis associated with ribavirin and didanosine therapy.
Butt AA. AIDS Read. 2003 Jul; 13(7):344-8.
Risk factors for symptomatic mitochondrial toxicity in HIV/hepatitis C virus-coinfected patients during interferon plus ribavirin-based therapy. [J Acquir Immune Defic Syndr. 2...]
Risk factors for symptomatic mitochondrial toxicity in HIV/hepatitis C virus-coinfected patients during interferon plus ribavirin-based therapy.
Bani-Sadr F, Carrat F, Pol S, Hor R, Rosenthal E, Goujard C, Morand P, Lunel-Fabiani F, Salmon-Ceron D, Piroth L, et al. J Acquir Immune Defic Syndr. 2005 Sep 1; 40(1):47-52.
Review [Treatment of chronic hepatitis C in patients coinfected with HIV: tolerability, drug interactions, therapeutic indications]. [Gastroenterol Clin Biol. 2002]
Review [Treatment of chronic hepatitis C in patients coinfected with HIV: tolerability, drug interactions, therapeutic indications].
Perronne C. Gastroenterol Clin Biol. 2002 Apr; 26 Spec No 2:B274-82.
Review Didanosine enteric-coated capsule: current role in patients with HIV-1 infection. [Drugs. 2007]
Review Didanosine enteric-coated capsule: current role in patients with HIV-1 infection.
Moreno S, Hernández B, Dronda F. Drugs. 2007; 67(10):1441-62.

See reviews... See all...

Cited by 3 PubMed Central articles

Mechanistic characterization of GS-9190 (Tegobuvir), a novel nonnucleoside inhibitor of hepatitis C virus NS5B polymerase. [Antimicrob Agents Chemother. 2...]
Mechanistic characterization of GS-9190 (Tegobuvir), a novel nonnucleoside inhibitor of hepatitis C virus NS5B polymerase.
Shih IH, Vliegen I, Peng B, Yang H, Hebner C, Paeshuyse J, Pürstinger G, Fenaux M, Tian Y, Mabery E, et al. Antimicrob Agents Chemother. 2011 Sep; 55(9):4196-203. Epub 2011 Jul 11.
Sustained long-term antiviral maintenance therapy in HCV/HIV-coinfected patients (SLAM-C). [J Acquir Immune Defic Syndr. 2...]
Sustained long-term antiviral maintenance therapy in HCV/HIV-coinfected patients (SLAM-C).
Sherman KE, Andersen JW, Butt AA, Umbleja T, Alston B, Koziel MJ, Peters MG, Sulkowski M, Goodman ZD, Chung RT, et al. J Acquir Immune Defic Syndr. 2010 Dec 15; 55(5):597-605.
Pharmacogenetics of nucleoside reverse-transcriptase inhibitor-associated peripheral neuropathy. [Pharmacogenomics. 2009]
Pharmacogenetics of nucleoside reverse-transcriptase inhibitor-associated peripheral neuropathy.
Kallianpur AR, Hulgan T. Pharmacogenomics. 2009 Apr; 10(4):623-37.

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Compound (MeSH Keyword)
PubChem chemical compound records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Nucleoside analogues and mitochondrial toxicity.
Nucleoside analogues and mitochondrial toxicity.
Clin Infect Dis. 2004 Apr 15 ;38(8):e79-80. Epub 2004 Mar 26 .

PubMed
The treatment of lymphedema related to breast cancer: a systematic review and ev...
The treatment of lymphedema related to breast cancer: a systematic review and evidence summary.
Support Care Cancer. 2004 Jun ;12(6):421-31. Epub 2004 Apr 17 .

PubMed
The never-ending story of peptide O-xylosyltransferase.
The never-ending story of peptide O-xylosyltransferase.
Cell Mol Life Sci. 2004 Apr ;61(7-8):794-809.

PubMed
Chest pain in pediatric patients presenting to an emergency department or to a c...
Chest pain in pediatric patients presenting to an emergency department or to a cardiac clinic.
Clin Pediatr (Phila). 2004 Apr ;43(3):231-8.

PubMed
The medical student experience with disasters and disaster response.
The medical student experience with disasters and disaster response.
CNS Spectr. 2002 Aug ;7(8):604-10.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to:

Nucleoside analogues and mitochondrial toxicity.

Source

Abstract

MeSH Terms, Substances

MeSH Terms

Substances

LinkOut - more resources

Full Text Sources

Other Literature Sources

Medical

Molecular Biology Databases

Supplemental Content

Save items

Related citations in PubMed

Cited by 3 PubMed Central articles

Related information

Recent activity

Simple NCBI Directory

Getting Started

Resources

Popular

Featured

NCBI Information