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Clin Infect Dis. 2004 Apr 15;38(8):e76-8. Epub 2004 Mar 29.

Failure of low-dose atovaquone prophylaxis against Pneumocystis jiroveci infection in transplant recipients.

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  • 1Division of Infectious Diseases, Massachusetts General Hospital, Boston, Massachusetts 02114, USA.


Trimethoprim-sulfamethoxazole is the preferred agent for prophylaxis against Pneumocystis jiroveci pneumonia. Alternative agents are used in treating patients who do not tolerate this medication. We report 2 cases of prophylaxis failure in patients receiving low-dose atovaquone. We discuss the use of atovaquone as an alternative agent for prophylaxis in transplant recipients.

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