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Cell Mol Life Sci. 2004 Apr;61(7-8):737-49.

All in the family: aldose reductase and closely related aldo-keto reductases.

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  • Department of Ophthalmology and Visual Sciences, Department of Genetics, Washington University School of Medicine, 660 South Euclid Avenue, St. Louis, Missouri 63110, USA. petrash@wustl.edu


Aldose reductase catalyzes the first step in the polyol pathway and is thought to be involved in the pathogenesis of diabetic complications. In addition to polyol synthesis, aldose reductase may have multiple other activities that intersect with signal processing and oxidative defense mechanisms. Multiple aldose reductase-like proteins have been discovered to have structures and catalytic properties that broadly overlap those of aldose reductase. This chapter will summarize new insights into properties and functions of aldose reductase and closely related members of the aldo-keto reductase enzyme superfamily.

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