Display Settings:


Send to:

Choose Destination
See comment in PubMed Commons below
Clin Appl Thromb Hemost. 2004 Apr;10(2):167-73.

Effect of ticlopidine on monocyte-derived microparticles and activated platelet markers in diabetes mellitus.

Author information

  • 1Osaka Saiseikai Izuo Hospital based on Social Welfare Organization Saiseikai Imperial Gift Foundation Inc., Kitamura, Osaka, Japan. tounyou@izuo-saiseikai.gr.jp


Platelet-derived microparticles, activated platelets, and monocyte-derived microparticles were measured in 73 patients with diabetes mellitus. A comparative study of these parameters was performed before and after administration of ticlopidine. The number of platelet-derived microparticles and activated platelets was increased significantly in diabetic patients. Monocyte-derived microparticles were also increased significantly. After administration of ticlopidine, platelet-derived microparticles and activated platelets corrected positively, not only CD62P- and CD63-positive platelets, but also platelet-derived microparticles and monocyte-derived microparticles showed a significant decrease. These data suggest that in patients with diabetes, platelet-derived microparticles and activated platelets stimulate the activation of monocytes and promote the production of monocyte-derived microparticles, and that ticlopidine is useful for hypercoagulabillity in diabetic patients.

[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Icon for HighWire
    Loading ...
    Write to the Help Desk