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Gene. 2004 Apr 28;331:107-14.

Heterogeneous nuclear ribonucleoprotein E2 binds to tau exon 10 and moderately activates its splicing.

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  • 1Neurobiology Division, Shriver Center at UMMS, Waltham, MA 02452, USA.


Tau is a microtubule-associated protein whose transcript undergoes complex-regulated splicing in the mammalian nervous system. Exon 10 of the gene is an alternatively spliced cassette, which is adult-specific and codes for a microtubule-binding domain. Mutations that affect splicing of exon 10 have been shown to cause frontotemporal dementia with parkinsonism (FTDP). Using tau exon 10 as a bait in a yeast three-hybrid screen, we discovered that it interacts with hnRNPE2. Cotransfection assays show that hnRNPE2 isoforms moderately activate the splicing of exon 10.

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