Format

Send to:

Choose Destination
See comment in PubMed Commons below
Gene. 2004 Apr 28;331:107-14.

Heterogeneous nuclear ribonucleoprotein E2 binds to tau exon 10 and moderately activates its splicing.

Author information

  • 1Neurobiology Division, Shriver Center at UMMS, Waltham, MA 02452, USA.

Abstract

Tau is a microtubule-associated protein whose transcript undergoes complex-regulated splicing in the mammalian nervous system. Exon 10 of the gene is an alternatively spliced cassette, which is adult-specific and codes for a microtubule-binding domain. Mutations that affect splicing of exon 10 have been shown to cause frontotemporal dementia with parkinsonism (FTDP). Using tau exon 10 as a bait in a yeast three-hybrid screen, we discovered that it interacts with hnRNPE2. Cotransfection assays show that hnRNPE2 isoforms moderately activate the splicing of exon 10.

PMID:
15094196
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Write to the Help Desk