Glossopyrosis (Glossodynie, Burning mouth syndrome) is not a independent diagnosis it is only a symptom of a lot clinical pictures. Local diseases like glossitis, allergies and tumors of the tongue are best known from ENT-doctors. But there are also gastrointestinal, immunologic, neurologic, psychiatric and dermatologic diseases cause glossopyrosis. Glossopyrosis may be the first symptom of HIV infection, Diabetes or a depression long before manifestation of the full clinical picture. Also dental materials and drugs are iatrogenic factors for glossopyrosis. The multifarious differential diagnosis were described and discussed.