Am J Med Sci. 2004 Apr;327(4):212-6.

An analog peptide that suppresses collagen-induced arthritis.

Myers LK, Sakurai Y, Rosloniec EF, Stuart JM, Kang AH.

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Department of Pediatrics and Medicine, University of Tennessee, and from the Research Service of the Veterans Affairs Medical Center, Memphis, Tennessee, USA. lmyers@utmem.edu

Abstract

The authors undertook the identification of peptides capable of altering the immune response to type II collagen (CII) in the context of HLA-DR, as suppressing the immune response to CII could clarify the role of CII autoimmunity in the pathogenesis of disease. To produce synthetic peptides with the potential of disrupting the DR1-restricted immune response, synthetic analog peptides were developed that contain site-directed substitutions in critical positions. When these analog peptides were used to treat collagen-induced arthritis in DR1 transgenic mice, an analog peptide, CII 256-276 (N, D), was identified that inhibited T-cell responses in vitro. The data from studies with this analog peptide establish that CII 256-276 (N, D) is a potent suppressor of the DR-mediated immune response to CII and that its effect is mediated, at least in part, by interleukin-4. An analog peptide of CII recognized by T cells in the context of a human major histocompatibility complex molecule should have therapeutic significance for autoimmune arthritis.

PMID:: 15084917; [PubMed - indexed for MEDLINE]

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Peptide-induced suppression of collagen-induced arthritis in HLA-DR1 transgenic mice. [Arthritis Rheum. 2002]
Peptide-induced suppression of collagen-induced arthritis in HLA-DR1 transgenic mice.
Myers LK, Sakurai Y, Tang B, He X, Rosloniec EF, Stuart JM, Kang AH. Arthritis Rheum. 2002 Dec; 46(12):3369-77.
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Sakurai Y, Brand DD, Tang B, Rosloniec EF, Stuart JM, Kang AH, Myers LK. Arthritis Res Ther. 2006; 8(5):R150.
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Rosloniec EF, Whittington KB, He X, Stuart JM, Kang AH. Am J Med Sci. 2004 Apr; 327(4):169-79.
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Review Immunopathogenesis of collagen arthritis.
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Review Transgenic mouse models of rheumatoid arthritis. [Immunol Rev. 1999]
Review Transgenic mouse models of rheumatoid arthritis.
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Cited by 4 PubMed Central articles

Polymerized-type I collagen induces upregulation of Foxp3-expressing CD4 regulatory T cells and downregulation of IL-17-producing CD4⁺ T cells (Th17) cells in collagen-induced arthritis. [Clin Dev Immunol. 2012]
Polymerized-type I collagen induces upregulation of Foxp3-expressing CD4 regulatory T cells and downregulation of IL-17-producing CD4⁺ T cells (Th17) cells in collagen-induced arthritis.
Furuzawa-Carballeda J, Macip-Rodríguez P, Galindo-Feria AS, Cruz-Robles D, Soto-Abraham V, Escobar-Hernández S, Aguilar D, Alpizar-Rodríguez D, Férez-Blando K, Llorente L. Clin Dev Immunol. 2012; 2012:618608. Epub 2011 Oct 19.
Modulation of collagen-induced arthritis by adenovirus-mediated intra-articular expression of modified collagen type II. [Arthritis Res Ther. 2010]
Modulation of collagen-induced arthritis by adenovirus-mediated intra-articular expression of modified collagen type II.
Tang B, Cullins DL, Zhou J, Zawaski JA, Park H, Brand DD, Hasty KA, Gaber MW, Stuart JM, Kang AH, et al. Arthritis Res Ther. 2010; 12(4):R136. Epub 2010 Jul 8.
Direct ex vivo analyses of HLA-DR1 transgenic mice reveal an exceptionally broad pattern of immunodominance in the primary HLA-DR1-restricted CD4 T-cell response to influenza virus hemagglutinin. [J Virol. 2007]
Direct ex vivo analyses of HLA-DR1 transgenic mice reveal an exceptionally broad pattern of immunodominance in the primary HLA-DR1-restricted CD4 T-cell response to influenza virus hemagglutinin.
Richards KA, Chaves FA, Krafcik FR, Topham DJ, Lazarski CA, Sant AJ. J Virol. 2007 Jul; 81(14):7608-19. Epub 2007 May 16.

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