Neurosci Lett. 1992 Jul 6;141(1):9-12.

Concentrations of serotonin and its related substances in the cerebrospinal fluid in patients with Alzheimer type dementia.

Tohgi H, Abe T, Takahashi S, Kimura M, Takahashi J, Kikuchi T.

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Department of Neurology, Iwate Medical University, Morioka, Japan.

Abstract

We studied concentrations of free and total serotonin (5-hydroxytryptamine, 5-HT) and its related substances in the cerebrospinal fluid from patients with Alzheimer type dementia (ATD) compared with controls. In ATD patients, concentrations of total 5-HT, tryptophan, 5-hydroxytryptophan (5-HTP), melatonin, kynurenine, and 3-hydroxykynurenine decreased significantly. The rate of concentration of tryptophan metabolites to that of tryptophan was significantly reduced for total 5-HT and 3-hydroxykynurenine only. The 5-hydroxyindoleacetic acid (5-HIAA)/5-HT ratio was significantly larger in ATD patients than in controls. The greater reduction in the 3-hydroxykynurenine concentration (81% vs. controls) than in the total 5-HT concentration (51% vs. controls) suggests that the metabolism of tryptophan to 5-HT and 3-hydroxykynurenine is in favor of 5-HT.

PMID:: 1508406; [PubMed - indexed for MEDLINE]

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