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    Med Hypotheses. 2004;62(5):718-20.

    Using immunomagnetic technology and other means to facilitate stem cell homing.

    Payne AG.

    Steenblock Research Institute, San Clemente, CA 92673, USA. dragpayne@yahoo.com

    If stem cell therapy is to be maximally effective, it is vital that progenitor (stem) cells get to the target tissue(s) and/or organ(s). Three methods of facilitating stem cell homing to target tissues are explored in this paper: (1) cobalt compounds such as cobalt phthalocyanines could be magnetically delivered to target tissue(s) and/or organ(s), and then subject to a brief pulsed magnetic field or ultrasound exposure suitable to induce mild hyperthermia with the result being the synthesis of cytokines that are chemoattractants to progenitor (stem) cells; (2) ferromagnetic nanobead particles could be tagged with antibodies specific to the target tissue(s) and/or organ(s) and infused into patients, followed by introduction of progenitor (stem) cells tagged with antibody-bound magnetic nanoparticles. This should result in passive attachment (stem cells to tagged tissue or organ); and (3) Reticulose, which stimulates the synthesis of the stem cell chemoattractant IL-8, could be magnetically guided to target tissue(s) and/or organ(s).

    PMID: 15082095 [PubMed - indexed for MEDLINE]

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