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Neurology. 2004 Apr 13;62(7):1110-4.

Stimulation of STN impairs aspects of cognitive control in PD.

Author information

  • 1Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63110, USA. tammy@npg.wustl.edu

Abstract

OBJECTIVE:

To test the hypothesis that subthalamic nucleus (STN) stimulation in Parkinson disease (PD) patients affects working memory and response inhibition performance, particularly under conditions of high demand on cognitive control.

METHODS:

To test this hypothesis, spatial working memory (spatial delayed response [SDR]) and response inhibition (Go-No-Go [GNG]) tasks requiring varying levels of cognitive control were administered to patients with PD with previously implanted bilateral STN stimulators (n = 24). Patients did not take PD medications overnight. Data were collected while bilateral stimulators were on and off, counterbalancing the order across subjects.

RESULTS:

On the SDR task, STN stimulation decreased patients' working memory performance under a high but not low memory load condition (effect of stimulator condition on high load only and condition x load interaction, p < 0.05). On the GNG task, STN stimulation reduced discriminability on a high but not medium inhibition condition (effect of stimulator condition on high inhibition level only, p = 0.05; condition x inhibition level interaction, p = 0.07).

CONCLUSION:

STN stimulation reduces working memory and response inhibition performance under conditions of greater challenge to cognitive control despite significant improvement of motor function.

PMID:
15079009
[PubMed - indexed for MEDLINE]
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