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J Org Chem. 2004 Apr 16;69(8):2906-9.

Leucosceptrine--a novel sesterterpene with prolylendopeptidase inhibitory activity from Leucosceptrum canum.

Author information

  • 1H. E. J. Research Institute of Chemistry, International Center for Chemical Sciences, University of Karachi, Karachi-75270, Pakistan. hej@cyber.net.pk

Abstract

A novel sesterterpene, leucosceptrine, was isolated from the medicinal plant Leucosceptrum canum from Nepal. The structure was determined by single-crystal X-ray diffraction and spectroscopic techniques. The biosynthesis of leucosceptrine (1) is proposed here. Leucosceptrine (1) exhibited prolylendopeptidase inhibitory activity.

PMID:
15074953
[PubMed - indexed for MEDLINE]
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