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1: Pharmacoepidemiol Drug Saf. 1998 Sep;7(5):319-22.Links

Postmarketing surveillance of the safety of cimetidine: 15-year mortality report.

Beresford J, Colin-Jones DG, Flind AC, Langman MJ, Lawson DH, Logan RF, Paterson KR, Vessey MP.

The Statwood Partnership, Hitchin, Herts, UK.

The pattern of mortality after 15 years of observation is reported among almost 10,000 patients who were taking cimetidine when they were first recruited between 1977 and 1980. Many took the drug for a number of years, some switching to other antisecretory agents as the study progressed. The findings are reassuring and provide no evidence of any long-term adverse effects of cimetidine which might be detected by monitoring mortality rates. The data have also been used to examine the possible positive relationships between aluminium ingestion and Alzheimer's disease and H. pylori infection and ischaemic heart disease. No significant evidence was obtained in support of the existence of these relationships. Copyright 1998 John Wiley & Sons, Ltd.

PMID: 15073978 [PubMed]

Patient Drug Information

  • Cimetidine (Tagamet® , Tagamet® HB, Tagamet® Tiltab® )

    Cimetidine is used to treat ulcers; gastroesophageal reflux disease (GERD), a condition in which backward flow of acid from the stomach causes heartburn and injury of the food pipe (esophagus); and conditions where the s...

  • Source: AHFS Consumer Medication Information