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Phytomedicine. 2004 Feb;11(2-3):261-3.

Anti-inflammatory agents from Sandoricum koetjape Merr.

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  • 1Forest Research Institute Malaysia, Kepong, Kuala Lumpur, Malaysia. rasadah@frim.gov.my

Abstract

The anti-inflammatory activity of the stem extracts of Sandoricum koetjape was investigated on topical administration using the TPA (tetradecanoylphorbol acetate)-induced mouse ear inflammation model. Bioassay-guided chromatographic fractionation of active fractions led to the isolation 3-oxo-12-oleanen-29-oic acid and katonic acid as the bioactive principles responsible for the anti-inflammatory acitivity. The percentage of inhibition exhibited by 3-oxo-12-oleanen-29-oic acid was almost equivalent to indomethacin.

PMID:
15070182
[PubMed - indexed for MEDLINE]
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