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1: Vaccine. 2004 Apr 16;22(13-14):1604-8.Click here to read Links

Genetic immunization against anthrax.

Galloway D, Liner A, Legutki J, Mateczun A, Barnewall R, Estep J.

Department of Microbiology, The Ohio State University, 484 West 12th Avenue, Columbus, OH 43210, USA. gallowayd@nmrc.navy.mil

The objective of this study was to determine whether a DNA prime-protein boost immunization against the Bacillus anthracis protective antigen (PA) and lethal factor (LF) antigens could induce a protective immune response against significant aerosol challenge in the rabbit model. Rabbits were vaccinated with different regimens of DNA vaccines (Table 1) and aerosol challenged with B. anthracis spores, Ames strain, with an average dose of 50 LD(50s) with a range from 18 to 169 LD(50s.) Of the five vaccinated rabbits that survived, two were immunized intramuscularly (i.m.) with DNA followed with a protein boost and three were immunized subcutaneous (s.q.) with recombinant protein. A major factor predicting survival was the ability of the animal to mount a lasting antibody response to PA. Rabbit sera were collected prior to and following aerosol challenge and titrated for PA antibodies by indirect ELISA. The results of this study indicate that DNA-based immunization against PA and LF induces significant protective immunity against aerosol challenge in the rabbit model and compares favorably with protein-based immunization.

PMID: 15068841 [PubMed - indexed for MEDLINE]

Patient Drug Information

  • Anthrax Vaccine (Biothrax® )

    Anthrax is a serious disease that can affect both animals and humans. It is caused by bacteria calledBacillus anthracis. People can get anthrax from contact with infected animals, wool, meat, or hides. In its most common...

  • Source: AHFS Consumer Medication Information

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