Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
Toxicol Ind Health. 2002 Aug;18(7):309-20.

Aluminum as a toxicant.

Author information

  • 1Department of Community and Environmental Medicine, Center for Occupational and Environmental Health Sciences, Irvine, CA 92697-1820, USA. abecaria@uci.edu

Abstract

Although aluminum is the most abundant metal in nature, it has no known biological function. However, it is known that there is a causal role for aluminum in dialysis encephalopathy, microcytic anemia, and osteomalacia. Aluminum has also been proposed to play a role in the pathogenesis of Alzheimer's disease (AD) even though this issue is controversial. The exact mechanism of aluminum toxicity is not known but accumulating evidence suggests that the metal can potentiate oxidative and inflammatory events, eventually leading to tissue damage. This review encompasses the general toxicology of aluminum with emphasis on the potential mechanisms by which it may accelerate the progression of chronic age-related neurodegenerative disorders.

PMID:
15068131
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Icon for HighWire
    Loading ...
    Write to the Help Desk