Comparison of combination therapy of adenosine and nitroprusside with adenosine alone in the treatment of angiographic no-reflow phenomenon

Catheter Cardiovasc Interv. 2004 Apr;61(4):484-91. doi: 10.1002/ccd.20010.

Abstract

We sought to compare the combination therapy of adenosine and nitroprusside in no-reflow phenomenon during percutaneous coronary intervention. Improvement in coronary flow from no-reflow to postdrug state was evaluated. Patients who received adenosine (n = 21) were compared to ones who received the combination of adenosine and nitroprusside (n = 20) for treatment. Improvement of TIMI flow grades was higher in the group that received combined therapy (1.5 +/- 1.0 vs. 0.8 +/- 0.6; P < 0.05). Combination therapy of adenosine and nitroprusside is safe and provides better improvement in coronary flow compared to intracoronary adenosine alone in case of impaired flow during coronary interventions.

Publication types

  • Comparative Study
  • Evaluation Study
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adenosine / administration & dosage
  • Adenosine / adverse effects
  • Adenosine / therapeutic use*
  • Aged
  • Aged, 80 and over
  • Angioplasty, Balloon, Coronary
  • Combined Modality Therapy
  • Coronary Angiography*
  • Coronary Circulation / drug effects*
  • Coronary Disease / physiopathology
  • Coronary Disease / therapy
  • Dose-Response Relationship, Drug
  • Drug Therapy, Combination
  • Female
  • Humans
  • Male
  • Middle Aged
  • Nitroprusside / administration & dosage
  • Nitroprusside / adverse effects
  • Nitroprusside / therapeutic use*
  • Severity of Illness Index
  • Treatment Outcome
  • Vasodilator Agents / administration & dosage
  • Vasodilator Agents / adverse effects
  • Vasodilator Agents / therapeutic use*

Substances

  • Vasodilator Agents
  • Nitroprusside
  • Adenosine