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Curr Opin Microbiol. 2004 Apr;7(2):109-14.

Structure of the histone-like protein H-NS and its role in regulation and genome superstructure.

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  • Enzymologie et Cinétique Structurale, LBPA, UMR 8113, Ecole Normale Supérieure de Cachan/CNRS/ Université Paris XI, 61 Avenue du Président Wilsons, 94235 Cachan cedex, France. rimsky@lbpa.ens-cachan.fr


H-NS belongs to the group of histone-like proteins in Gram-negative bacteria and is also a pleiotropic regulator of genes implicated in many responses to environmental changes. It plays a dual role in structuring DNA and in regulating transcription. Recent advances have been made in elucidating the structure and oligomerisation properties of this protein, thus aiding in the understanding of the molecular relationship between its two major functions.

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