Curr Biol. 2004 Apr 6;14(7):R284-6.

Genomic imprinting: CTCF protects the boundaries.

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Laboratory of Developmental Genetics and Imprinting, Developmental Genetics Programme, The Babraham Institute, Cambridge, CB2 4AT, UK.

Abstract

The DNA-binding protein CTCF, which acts as a chromatin 'insulator', regulates imprinting of the mammalian Igf2 and H19 genes in a methylation-sensitive manner. It has now been shown that CTCF is also required for protection against de novo methylation of the differentially methylated domain of H19 in the female germline.

PMID:: 15062124; [PubMed - indexed for MEDLINE]

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Mutation of a single CTCF target site within the H19 imprinting control region leads to loss of Igf2 imprinting and complex patterns of de novo methylation upon maternal inheritance. [Mol Cell Biol. 2004]
Mutation of a single CTCF target site within the H19 imprinting control region leads to loss of Igf2 imprinting and complex patterns of de novo methylation upon maternal inheritance.
Pant V, Kurukuti S, Pugacheva E, Shamsuddin S, Mariano P, Renkawitz R, Klenova E, Lobanenkov V, Ohlsson R. Mol Cell Biol. 2004 Apr; 24(8):3497-504.
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CTCF binding at the H19 imprinting control region mediates maternally inherited higher-order chromatin conformation to restrict enhancer access to Igf2.
Kurukuti S, Tiwari VK, Tavoosidana G, Pugacheva E, Murrell A, Zhao Z, Lobanenkov V, Reik W, Ohlsson R. Proc Natl Acad Sci U S A. 2006 Jul 11; 103(28):10684-9. Epub 2006 Jun 30.
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CTCF-dependent chromatin bias constitutes transient epigenetic memory of the mother at the H19-Igf2 imprinting control region in prospermatogonia.
Lee DH, Singh P, Tsai SY, Oates N, Spalla A, Spalla C, Brown L, Rivas G, Larson G, Rauch TA, et al. PLoS Genet. 2010 Nov 24; 6(11):e1001224. Epub 2010 Nov 24.
Review Transcriptional control: imprinting insulation. [Curr Biol. 2000]
Review Transcriptional control: imprinting insulation.
Wolffe AP. Curr Biol. 2000 Jun 15; 10(12):R463-5.
Review CTCF function is modulated by neighboring DNA binding factors. [Biochem Cell Biol. 2011]
Review CTCF function is modulated by neighboring DNA binding factors.
Weth O, Renkawitz R. Biochem Cell Biol. 2011 Oct; 89(5):459-68. Epub 2011 Sep 7.

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Cited by 16 PubMed Central articles

ADP-ribose polymers localized on Ctcf-Parp1-Dnmt1 complex prevent methylation of Ctcf target sites. [Biochem J. 2012]
ADP-ribose polymers localized on Ctcf-Parp1-Dnmt1 complex prevent methylation of Ctcf target sites.
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Epigenetic profile of the euchromatic region of human Y chromosome. [Nucleic Acids Res. 2011]
Epigenetic profile of the euchromatic region of human Y chromosome.
Singh NP, Madabhushi SR, Srivastava S, Senthilkumar R, Neeraja C, Khosla S, Mishra RK. Nucleic Acids Res. 2011 May; 39(9):3594-606. Epub 2011 Jan 19.
The Drosophila homolog of the mammalian imprint regulator, CTCF, maintains the maternal genomic imprint in Drosophila melanogaster. [BMC Biol. 2010]
The Drosophila homolog of the mammalian imprint regulator, CTCF, maintains the maternal genomic imprint in Drosophila melanogaster.
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Genomic imprinting: CTCF protects the boundaries.
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Genomic imprinting: CTCF protects the boundaries.

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