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    Genomics. 1992 Aug;13(4):962-7.

    Chromosomal localization of seven neuronal nicotinic acetylcholine receptor subunit genes in humans.

    Anand R, Lindstrom J.

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    David Mahoney Institute of Neurological Sciences, University of Pennsylvania, Philadelphia 19104-6074.

    Abstract

    We have determined the chromosomal location of seven human neuronal nicotinic acetylcholine receptor subunit genes by genomic Southern analysis of hamster/human somatic cell hybrid DNAs. The beta 2 subunit gene was localized to human chromosome 1, the alpha 2 and beta 3 subunit genes were localized to human chromosome 8, the alpha 3, alpha 5, and beta 4 subunit genes were localized to human chromosome 15, and the alpha 4 subunit gene was localized to human chromosome 20. Mapping of the beta 2 subunit gene to chromosome 1 establishes a syntenic group with the amylase gene locus on human chromosome 1 and mouse chromosome 3, while mapping of the alpha 3 subunit gene to chromosome 15 confirms the existence of a syntenic group with the mannose phosphate isomerase gene locus on human chromosome 15 and mouse chromosome 9.

    PMID:
    1505988
    [PubMed - indexed for MEDLINE]

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