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    Genomics. 1992 Aug;13(4):1347-9.

    Complementary physical and genetic techniques map the vinculin (VCL) gene on chromosome 10q.

    Mulligan LM, Gardner E, Telenius H, Ponder BA.

    Department of Pathology, University of Cambridge, United Kingdom.

    Vinculin is a cytoskeletal protein component of adherens type cell junctions. The gene had been mapped to 10q11.2-qter. We have used a combination of physical and genetic mapping techniques to refine this localization. Hybridization of the vinculin cDNA probe, HV1, to a human-rodent somatic hybrid panel initially suggested a position of either 10q11.2 or 10q22.1-10q23. Genetic recombination mapping in three-generation families with multiple endocrine neoplasia type 2 (MEN2) indicated a position distal to D10S22 (10q21.1) in 10q22.1-10q23. This was confirmed by hybridization of the vinculin cDNA to flow-sorted translocation derivative chromosomes containing the q21-qter portion of chromosome 10. We conclude that the vinculin locus maps in 10q22.1-q23, distal to D10S22.

    PMID: 1505973 [PubMed - indexed for MEDLINE]

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