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Genome Biol. 2004;5(4):218. Epub 2004 Mar 30.

Nonsense-mediated mRNA decay: from vacuum cleaner to Swiss army knife.

Author information

  • 1Department of Pediatric Oncology, Hematology and Immunology, University of Heidelberg, Im Neuenheimer Feld 150, 69120 Heidelberg, Germany. gaby.neu-yilik@med.uni-heidelberg.de

Abstract

Nonsense-mediated mRNA decay (NMD) downmodulates mRNAs that have in-frame premature termination codons and prevents translation of potentially harmful truncated proteins from aberrant mRNAs. Two new approaches have identified physiological NMD substrates, and suggest that NMD functions as a multipurpose tool in the modulation of gene expression.

PMID:
15059251
[PubMed - indexed for MEDLINE]
PMCID:
PMC395777
Free PMC Article

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