Your browser version may not work well with NCBI's Web applications. More information here...
1: Genome Biol. 2004;5(4):218. Epub 2004 Mar 30.Click here to read Click here to read Links

Nonsense-mediated mRNA decay: from vacuum cleaner to Swiss army knife.

Neu-Yilik G, Gehring NH, Hentze MW, Kulozik AE.

Department of Pediatric Oncology, Hematology and Immunology, University of Heidelberg, Im Neuenheimer Feld 150, 69120 Heidelberg, Germany. gaby.neu-yilik@med.uni-heidelberg.de

Nonsense-mediated mRNA decay (NMD) downmodulates mRNAs that have in-frame premature termination codons and prevents translation of potentially harmful truncated proteins from aberrant mRNAs. Two new approaches have identified physiological NMD substrates, and suggest that NMD functions as a multipurpose tool in the modulation of gene expression.

PMID: 15059251 [PubMed - indexed for MEDLINE]

PMCID: PMC395777