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1: Genome Biol. 2004;5(4):105. Epub 2004 Mar 25.Click here to read Click here to read Links

The mammalian transcriptome and the function of non-coding DNA sequences.

Shabalina SA, Spiridonov NA.

National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD 20894, USA. shabalin@ncbi.nlm.nih.gov

For decades, researchers have focused most of their attention on protein-coding genes and proteins. With the completion of the human and mouse genomes and the accumulation of data on the mammalian transcriptome, the focus now shifts to non-coding DNA sequences, RNA-coding genes and their transcripts. Many non-coding transcribed sequences are proving to have important regulatory roles, but the functions of the majority remain mysterious.

PMID: 15059247 [PubMed - indexed for MEDLINE]

PMCID: PMC395773