Zhong Yao Cai. 2003 Dec;26(12):870-3.

[Effect of total triterpenes from Centella asiatica on the depression behavior and concentration of amino acid in forced swimming mice].

[Article in Chinese]

Chen Y, Han T, Qin L, Rui Y, Zheng H.

Source

School of Pharmacy, Second Military Medical University, Shanghai 200433.

Abstract

OBJECTIVE:

To evaluate the antidepressant activity of total triterpenes from Centella asiatica in forced swimming test.

METHODS:

Mice were randomly divided into control group, model group and treatment group. The effect of total triterpenes from Centella asiatica on the immobility time in forced swimming mice and concentration of amino acid in mice brain tissue was observed.

RESULTS:

Imipramine and total triterpenes from Centella asiatica reduced the immobility time and ameliorated the imbalance of amino acid levels.

CONCLUSION:

The total triterpenes from Centella asiatica had antidepressant activity.

PMID:: 15058206; [PubMed - indexed for MEDLINE]

LinkOut - more resources

Medical

Molecular Biology Databases

IMIPRAMINE - HSDB

Supplemental Content

Save items

Related citations in PubMed

[Effects of total triterpenes of Centella asiatica on the corticosterone levels in serum and contents of monoamine in depression rat brain]. [Zhong Yao Cai. 2005]
[Effects of total triterpenes of Centella asiatica on the corticosterone levels in serum and contents of monoamine in depression rat brain].
Chen Y, Han T, Rui Y, Yin M, Qin L, Zheng H. Zhong Yao Cai. 2005 Jun; 28(6):492-6.
Forced swimming and imipramine modify plasma and brain amino acid concentrations in mice. [Eur J Pharmacol. 2009]
Forced swimming and imipramine modify plasma and brain amino acid concentrations in mice.
Murakami T, Yamane H, Tomonaga S, Furuse M. Eur J Pharmacol. 2009 Jan 5; 602(1):73-7. Epub 2008 Nov 6.
Antidepressant-like effects of the ethanolic extract of Xiaobuxin-Tang, a traditional Chinese herbal prescription in animal models of depression. [Chin Med J (Engl). 2007]
Antidepressant-like effects of the ethanolic extract of Xiaobuxin-Tang, a traditional Chinese herbal prescription in animal models of depression.
Zhang YZ, Li YF, Yu NJ, Yuan L, Zhao YM, Xiao WB, Luo ZP. Chin Med J (Engl). 2007 Oct 20; 120(20):1792-6.
Review Is the forced swimming test a suitable model for revealing antidepressant activity? [Psychopharmacology (Berl). 1988]
Review Is the forced swimming test a suitable model for revealing antidepressant activity?
Borsini F, Meli A. Psychopharmacology (Berl). 1988; 94(2):147-60.
Review Chemical components of Centella asiatica and their bioactivities. [Zhong Xi Yi Jie He Xue Bao. 2007]
Review Chemical components of Centella asiatica and their bioactivities.
Zheng CJ, Qin LP. Zhong Xi Yi Jie He Xue Bao. 2007 May; 5(3):348-51.

See reviews... See all...

Cited by 3 PubMed Central articles

Evaluation of antioxidant activity of two important memory enhancing medicinal plants Baccopa monnieri and Centella asiatica. [Indian J Pharmacol. 2012]
Evaluation of antioxidant activity of two important memory enhancing medicinal plants Baccopa monnieri and Centella asiatica.
Meena H, Pandey HK, Pandey P, Arya MC, Ahmed Z. Indian J Pharmacol. 2012 Jan; 44(1):114-7.
Pharmacological Review on Centella asiatica: A Potential Herbal Cure-all. [Indian J Pharm Sci. 2010]
Pharmacological Review on Centella asiatica: A Potential Herbal Cure-all.
Gohil KJ, Patel JA, Gajjar AK. Indian J Pharm Sci. 2010 Sep; 72(5):546-56.
Centella asiatica Improves Physical Performance and Health-related Quality of Life in Healthy Elderly Volunteer. [Evid Based Complement Alternat...]
Centella asiatica Improves Physical Performance and Health-related Quality of Life in Healthy Elderly Volunteer.
Mato L, Wattanathorn J, Muchimapura S, Tongun T, Piyawatkul N, Yimtae K, Thanawirattananit P, Sripanidkulchai B. Evid Based Complement Alternat Med. 2009 Oct 30; . Epub 2009 Oct 30.

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Compound (MeSH Keyword)
PubChem chemical compound records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

[Effect of total triterpenes from Centella asiatica on the depression behavior a...
[Effect of total triterpenes from Centella asiatica on the depression behavior and concentration of amino acid in forced swimming mice].
Zhong Yao Cai. 2003 Dec ;26(12):870-3.

PubMed
[Ammonia and GABA-ergic neurotransmission in pathogenesis of hepatic encephalopa...
[Ammonia and GABA-ergic neurotransmission in pathogenesis of hepatic encephalopathy].
Wiad Lek. 2003 ;56(11-12):560-3.

PubMed
Diagnosis, management, and treatment of hepatitis C.
Diagnosis, management, and treatment of hepatitis C.
Hepatology. 2004 Apr ;39(4):1147-71.

PubMed
A breast cancer prediction model incorporating familial and personal risk factor...
A breast cancer prediction model incorporating familial and personal risk factors.
Stat Med. 2004 Apr 15 ;23(7):1111-30.

PubMed
Genome sequence of the Brown Norway rat yields insights into mammalian evolution...
Genome sequence of the Brown Norway rat yields insights into mammalian evolution.
Nature. 2004 Apr 1 ;428(6982):493-521.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to:

[Effect of total triterpenes from Centella asiatica on the depression behavior and concentration of amino acid in forced swimming mice].

Source

Abstract

OBJECTIVE:

METHODS:

RESULTS:

CONCLUSION:

Publication Types, MeSH Terms, Substances

Publication Types

MeSH Terms

Substances

LinkOut - more resources

Medical

Molecular Biology Databases

Supplemental Content

Save items

Related citations in PubMed

Cited by 3 PubMed Central articles

Related information

Recent activity

Simple NCBI Directory

Getting Started

Resources

Popular

Featured

NCBI Information