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The DNA sequence and analysis of human chromosome 13.
Dunham A,
Matthews LH,
Burton J,
Ashurst JL,
Howe KL,
Ashcroft KJ,
Beare DM,
Burford DC,
Hunt SE,
Griffiths-Jones S,
Jones MC,
Keenan SJ,
Oliver K,
Scott CE,
Ainscough R,
Almeida JP,
Ambrose KD,
Andrews DT,
Ashwell RI,
Babbage AK,
Bagguley CL,
Bailey J,
Bannerjee R,
Barlow KF,
Bates K,
Beasley H,
Bird CP,
Bray-Allen S,
Brown AJ,
Brown JY,
Burrill W,
Carder C,
Carter NP,
Chapman JC,
Clamp ME,
Clark SY,
Clarke G,
Clee CM,
Clegg SC,
Cobley V,
Collins JE,
Corby N,
Coville GJ,
Deloukas P,
Dhami P,
Dunham I,
Dunn M,
Earthrowl ME,
Ellington AG,
Faulkner L,
Frankish AG,
Frankland J,
French L,
Garner P,
Garnett J,
Gilbert JG,
Gilson CJ,
Ghori J,
Grafham DV,
Gribble SM,
Griffiths C,
Hall RE,
Hammond S,
Harley JL,
Hart EA,
Heath PD,
Howden PJ,
Huckle EJ,
Hunt PJ,
Hunt AR,
Johnson C,
Johnson D,
Kay M,
Kimberley AM,
King A,
Laird GK,
Langford CJ,
Lawlor S,
Leongamornlert DA,
Lloyd DM,
Lloyd C,
Loveland JE,
Lovell J,
Martin S,
Mashreghi-Mohammadi M,
McLaren SJ,
McMurray A,
Milne S,
Moore MJ,
Nickerson T,
Palmer SA,
Pearce AV,
Peck AI,
Pelan S,
Phillimore B,
Porter KM,
Rice CM,
Searle S,
Sehra HK,
Shownkeen R,
Skuce CD,
Smith M,
Steward CA,
Sycamore N,
Tester J,
Thomas DW,
Tracey A,
Tromans A,
Tubby B,
Wall M,
Wallis JM,
West AP,
Whitehead SL,
Willey DL,
Wilming L,
Wray PW,
Wright MW,
Young L,
Coulson A,
Durbin R,
Hubbard T,
Sulston JE,
Beck S,
Bentley DR,
Rogers J,
Ross MT.
The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire, CB10 1SA, UK. ad1@sanger.ac.uk
Chromosome 13 is the largest acrocentric human chromosome. It carries genes involved in cancer including the breast cancer type 2 (BRCA2) and retinoblastoma (RB1) genes, is frequently rearranged in B-cell chronic lymphocytic leukaemia, and contains the DAOA locus associated with bipolar disorder and schizophrenia. We describe completion and analysis of 95.5 megabases (Mb) of sequence from chromosome 13, which contains 633 genes and 296 pseudogenes. We estimate that more than 95.4% of the protein-coding genes of this chromosome have been identified, on the basis of comparison with other vertebrate genome sequences. Additionally, 105 putative non-coding RNA genes were found. Chromosome 13 has one of the lowest gene densities (6.5 genes per Mb) among human chromosomes, and contains a central region of 38 Mb where the gene density drops to only 3.1 genes per Mb.
PMID: 15057823 [PubMed - indexed for MEDLINE]
PMCID: PMC2665288
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Cited by 6 PubMed Central articles
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Independent centromere formation in a capricious, gene-free domain of chromosome 13q21 in Old World monkeys and pigs.
Cardone MF, Alonso A, Pazienza M, Ventura M, Montemurro G, Carbone L, de Jong PJ, Stanyon R, D'Addabbo P, Archidiacono N, et al.
Genome Biol. 2006; 7(10):R91. Epub 2006 Oct 13.
[Genome Biol. 2006]
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ReviewEGASP: the human ENCODE Genome Annotation Assessment Project.
Guigó R, Flicek P, Abril JF, Reymond A, Lagarde J, Denoeud F, Antonarakis S, Ashburner M, Bajic VB, Birney E, et al.
Genome Biol. 2006; 7 Suppl 1:S2.1-31. Epub 2006 Aug 7.
[Genome Biol. 2006]
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ReviewSchizophrenia: an integrative approach to modelling a complex disorder.
Robertson GS, Hori SE, Powell KJ.
J Psychiatry Neurosci. 2006 May; 31(3):157-67.
[J Psychiatry Neurosci. 2006]
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