Nature. 2004 Apr 1;428(6982):486.

Medical genetics: a marker for Stevens-Johnson syndrome.

Chung WH, Hung SI, Hong HS, Hsih MS, Yang LC, Ho HC, Wu JY, Chen YT.

Source

Department of Dermatology, Chang Gung Memorial Hospital, Taipei, Taiwan.

Abstract

Stevens-Johnson syndrome and the related disease toxic epidermal necrolysis are life-threatening reactions of the skin to particular types of medication. Here we show that there is a strong association in Han Chinese between a genetic marker, the human leukocyte antigen HLA-B*1502, and Stevens-Johnson syndrome induced by carbamazepine, a drug commonly prescribed for the treatment of seizures. It should be possible to exploit this association in a highly reliable test to predict severe adverse reaction, as well as for investigation of the pathogenesis of Stevens-Johnson syndrome.

PMID:: 15057820; [PubMed - indexed for MEDLINE]

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Association of HLA-B*1502 allele with carbamazepine-induced toxic epidermal necrolysis and Stevens-Johnson syndrome in the multi-ethnic Malaysian population. [Int J Dermatol. 2011]
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