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Am J Psychiatry. 2004 Apr;161(4):736-8.

Cognitive functioning in late-life bipolar disorder.

Author information

  • 1Information Research Center for Late-Life Mood Disorders, Department of Psychiatry, University of Pittsburgh School of Medicine, PA 15213, USA. gildengersag@upmc.edu

Abstract

OBJECTIVE:

This study characterized cognitive functioning in elderly patients with bipolar disorder.

METHOD:

The cognitive functioning of 18 euthymic patients with a history of bipolar disorder I or II, ages 60 years and older, was tested with the Mini-Mental State Examination (MMSE), the Mattis Dementia Rating Scale, and the Executive Interview. Cognitive functioning in these subjects was compared with that of an age- and education-matched group of 45 comparison subjects without mood disorders.

RESULTS:

Approximately half of the bipolar subjects scored one or more standard deviations below the mean of the comparison subjects on the MMSE (N=8, 44%) and the Mattis Dementia Rating Scale total (N=10, 56%). On the Executive Interview, three subjects (17%) scored between one and two standard deviations below the mean of the comparison subjects.

CONCLUSIONS:

A significant proportion of older bipolar subjects exhibited neuropsychological deficits when they were clinically euthymic.

PMID:
15056521
[PubMed - indexed for MEDLINE]
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