Eur Neurol. 1992;32(4):190-4.

Enumeration of T, B and natural killer peripheral blood cells of patients with multiple sclerosis and controls.

Kreuzfelder E, Shen G, Bittorf M, Scheiermann N, Thraenhart O, Seidel D, Grosse-Wilde H.

Source

Institut für Medizinische Virologie, Universität-Gesamthochschule Essen, FRG.

Abstract

The median percentages of peripheral blood immunoglobulin-positive (Ig+) lymphocytes (8%, n = 46), CD8+ (12%, n = 49) and CD57+ cell numbers (5%, n = 37) of patients suffering from multiple sclerosis (MS) were significantly (p less than 0.05) lower than the values of age- and sex-matched healthy individuals (Ig+ cells: 13%, n = 46; CD8+ cells: 17%, n = 49; CD57+ cells: 9%, n = 37). Comparison of calculations on decreased peripheral blood cell counts and increased brain cell counts in MS patients revealed that sequestration of blood cells into the MS brain is a possible explanation of these findings.

PMID:: 1505587; [PubMed - indexed for MEDLINE]

MeSH Terms

LinkOut - more resources

Other Literature Sources

Labome Researcher Resource - ExactAntigen/Labome

Medical

Multiple Sclerosis - MedlinePlus Health Information

Supplemental Content

Save items

Related citations in PubMed

Alterations in levels of CD28-/CD8+ suppressor cell precursor and CD45RO+/CD4+ memory T lymphocytes in the peripheral blood of multiple sclerosis patients. [Clin Diagn Lab Immunol. 1995]
Alterations in levels of CD28-/CD8+ suppressor cell precursor and CD45RO+/CD4+ memory T lymphocytes in the peripheral blood of multiple sclerosis patients.
Crucian B, Dunne P, Friedman H, Ragsdale R, Pross S, Widen R. Clin Diagn Lab Immunol. 1995 Mar; 2(2):249-52.
CD4 and CD8 lymphocyte subsets in cerebrospinal fluid and peripheral blood from patients with multiple sclerosis, meningitis and normal controls. [Acta Neurol Scand. 1998]
CD4 and CD8 lymphocyte subsets in cerebrospinal fluid and peripheral blood from patients with multiple sclerosis, meningitis and normal controls.
Vrethem M, Dahle C, Ekerfelt C, Forsberg P, Danielsson O, Ernerudh J. Acta Neurol Scand. 1998 Apr; 97(4):215-20.
Shigella infection induces cellular activation of T and B cells and distinct species-related changes in peripheral blood lymphocyte subsets during the course of the disease. [Infect Immun. 1995]
Shigella infection induces cellular activation of T and B cells and distinct species-related changes in peripheral blood lymphocyte subsets during the course of the disease.
Islam D, Bardhan PK, Lindberg AA, Christensson B. Infect Immun. 1995 Aug; 63(8):2941-9.
Review Studies of interferon production and natural killing by lymphocytes from multiple sclerosis patients. [Ann N Y Acad Sci. 1984]
Review Studies of interferon production and natural killing by lymphocytes from multiple sclerosis patients.
Neighbour PA. Ann N Y Acad Sci. 1984; 436:181-91.
Review [Multiple sclerosis and regulatory cells]. [Nihon Rinsho. 2005]
Review [Multiple sclerosis and regulatory cells].
Yamamura T, Takahashi K, Araki M. Nihon Rinsho. 2005 May; 63 Suppl 5:422-6.

See reviews... See all...

Cited by 4 PubMed Central articles

CD8+ T-Cell Deficiency, Epstein-Barr Virus Infection, Vitamin D Deficiency, and Steps to Autoimmunity: A Unifying Hypothesis. [Autoimmune Dis. 2012]
CD8+ T-Cell Deficiency, Epstein-Barr Virus Infection, Vitamin D Deficiency, and Steps to Autoimmunity: A Unifying Hypothesis.
Pender MP. Autoimmune Dis. 2012; 2012:189096. Epub 2012 Jan 24.
Decreased CD8+ T cell response to Epstein-Barr virus infected B cells in multiple sclerosis is not due to decreased HLA class I expression on B cells or monocytes. [BMC Neurol. 2011]
Decreased CD8+ T cell response to Epstein-Barr virus infected B cells in multiple sclerosis is not due to decreased HLA class I expression on B cells or monocytes.
Pender MP, Csurhes PA, Pfluger CM, Burrows SR. BMC Neurol. 2011 Aug 3; 11:95. Epub 2011 Aug 3.
Review Regulatory NK-cell functions in inflammation and autoimmunity. [Mol Med. 2009]
Review Regulatory NK-cell functions in inflammation and autoimmunity.
Lünemann A, Lünemann JD, Münz C. Mol Med. 2009 Sep-Oct; 15(9-10):352-8. Epub 2009 May 11.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Enumeration of T, B and natural killer peripheral blood cells of patients with m...
Enumeration of T, B and natural killer peripheral blood cells of patients with multiple sclerosis and controls.
Eur Neurol. 1992 ;32(4):190-4.

PubMed
Long-term glycaemic control with pioglitazone in patients with type 2 diabetes.
Long-term glycaemic control with pioglitazone in patients with type 2 diabetes.
Int J Clin Pract. 2004 Feb ;58(2):192-200.

PubMed
Hypergalactosaemia and portosystemic encephalopathy due to persistence of ductus...
Hypergalactosaemia and portosystemic encephalopathy due to persistence of ductus venosus Arantii.
Eur J Pediatr. 1992 Aug ;151(8):564-8.

PubMed
The search for odorant receptors.
The search for odorant receptors.
Cell. 2004 Jan 23 ;116(2 Suppl):S117-9, 1 p following S119.

PubMed
ZIP codes for delivering SH2 domains.
ZIP codes for delivering SH2 domains.
Cell. 2004 Jan 23 ;116(2 Suppl):S41-3, 2 p following S48.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to:

Enumeration of T, B and natural killer peripheral blood cells of patients with multiple sclerosis and controls.

Source

Abstract

MeSH Terms

MeSH Terms

LinkOut - more resources

Other Literature Sources

Medical

Supplemental Content

Save items

Related citations in PubMed

Cited by 4 PubMed Central articles

Related information

Recent activity

Simple NCBI Directory

Getting Started

Resources

Popular

Featured

NCBI Information