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Cancer Lett. 2004 Apr 15;207(1):109-15.

Ki-67 and CEA expression as prognostic markers in Dukes' C colorectal cancer.

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  • 1Department of Surgery, Sakai Municipal Hospital, 1-1-1 Minamiyasuichou, Sakai 590-0064, Japan. colon777@par.odn.ne.jp


This study investigated the relationship between clinicopathological or immunohistochemical factors and postoperative prognosis for Dukes' C colorectal cancer. Short-term survivors died from cancer within 2 years of surgery, whereas long-term survivors were disease-free for over 10 years. The groups differed in Ki-67 antigen and CEA expression in colon cancer, and CEA expression in rectal cancer that was limited to the metastatic lymph nodes. The immunohistochemical scores were higher in short-term survivors. Our data suggest that the characteristics of metastatic lymph nodes are important as a predictor of the aggressiveness of tumor behavior and that the expression of Ki-67 antigen or CEA there may be a useful indicators of patients' survival in Dukes' C colorectal cancer.

[PubMed - indexed for MEDLINE]
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