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Trends Genet. 2004 Mar;20(3):126-31.

Global analysis of bacterial transcription factors to predict cellular target processes.

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  • 1EMBL, 69117 Heidelberg, Meyerhofstr 1, Germany.


Whole-genome sequences are now available for >100 bacterial species, giving unprecedented power to comparative genomics approaches. We have applied genome-context methods to predict target processes that are regulated by transcription factors (TFs). Of 128 orthologous groups of proteins annotated as TFs, to date, 36 are functionally uncharacterized; in our analysis we predict a probable cellular target process or biochemical pathway for half of these functionally uncharacterized TFs.

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