Format

Send to:

Choose Destination
See comment in PubMed Commons below
Pol J Pharmacol. 2004 Jan-Feb;56(1):43-9.

Gamma-hydrobutyric acid (GHB) and its chemical modifications: a review of the GHBergic system.

Author information

  • 1Department of Organic Chemistry, Jagiellonian University Medical College, Medyczna 9, PL 30-688 Krak√≥w, Poland. AM.Waszkielewicz@interia.pl

Abstract

Gamma-hydroxybutyric acid (GHB) is a naturally occurring substance with function of an inhibitory neurotransmitter in the central nervous system in mammals. GHB can be used as a medicine in narcolepsy (Xyrem) and for general anesthesia (sodium oxybate). It is also a popular drug of abuse, causing coma, addiction and severe withdrawal syndrome, and, therefore, demanding thorough studies on the GHBergic system and expanded research on toxicology of this compound. The aim of this review is to present the proved and some suggested mechanisms of its action from pharmacological point of view, which may help to properly treat intoxication or other pathological states caused by GHB ingestion. Some new GHB derivatives studied for analogous action and their present use are also described.

PMID:
15047976
[PubMed - indexed for MEDLINE]
Free full text
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Institute of Pharmacology Polish Academy of Sciences
    Loading ...
    Write to the Help Desk