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Antimicrob Agents Chemother. 2004 Apr;48(4):1422-5.

2'-fluoro-2'-deoxycytidine inhibits Borna disease virus replication and spread.

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  • 1Unité des Virus Lents, CNRS URA 1930, Institut Pasteur, Paris, France.


Borna disease virus (BDV) causes neurological diseases in a variety of warm-blooded animal species, possibly including humans. To date, there is no effective treatment against BDV infection. Recently, we reported on the antiviral activity of 1-beta-D-arabinofuranosylcytosine (Ara-C). However, Ara-C's cytotoxic side effects are a major obstacle for its therapeutic use. Herein, we demonstrate that the nucleoside analog 2'-fluoro-2'-deoxycytidine (2'-FdC) exhibits potent antiviral activity against BDV. Importantly, 2'-FdC-associated cytotoxicity is negligible, indicating 2'-FdC as an excellent candidate for the development of antiviral therapy against BDV.

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