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Clin Immunol. 2004 Mar;110(3):243-51.

HLA-Ig-based artificial antigen-presenting cells: setting the terms of engagement.

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  • 1Department of Pathology and Medicine, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA.


Recent advances in molecular medicine have shown that soluble MHC-multimers can be valuable tools for both the stimulation of as well as the analysis of antigen-specific T cells in vitro. In this review, we describe the use of dimeric major histocompatibility complexes, HLA-Ig, to visualize antigen-specific T cells as well as their potential to stimulate immune responses as part of an artificial antigen-presenting cell (aAPC). The use of HLA-Ig-based aAPC represents an exciting new approach to generate antigen-specific CTL for adoptive immunotherapy that helps to overcome many of the obstacles associated with limitations in current approaches to adoptive immunotherapy.

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