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Neuron. 2004 Mar 25;41(6):841-2.

A touching picture of nicotinic binding.

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  • 1Center for Molecular Recognition, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA.

Abstract

The snail acetylcholine binding protein (AChBP) is homologous to the extracellular domains of the nicotinic ACh receptors. In this issue of Neuron, Celie et al. show how the crystal structures of AChBP in complexes with carbamylcholine and nicotine reveal the basis for agonist recognition by ACh receptors.

PMID:
15046715
[PubMed - indexed for MEDLINE]
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