Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
Physiol Res. 2004;53(2):123-9.

Adiponectin and its role in the obesity-induced insulin resistance and related complications.

Author information

  • 1Third Department of Medicine, First Faculty of Medicine, Charles University, U nemocnice 1, 128 08, Praha 2, Czech Republic. mhalu@lf1.cuni.cz

Abstract

It is now generally accepted that adipose tissue acts as an endocrine organ producing a number of substances with an important role in the regulation of food intake, energy expenditure and a series of metabolic processes. Adiponectin is a recently discovered protein produced exclusively by adipocytes. A number of studies have shown that obesity, insulin resistance and atherosclerosis are accompanied by decreased adiponectin levels and that adiponectin replacement under experimental settings is able to diminish both insulin resistance and atherosclerosis. The aim of this review is to summarize the current knowledge about the physiology and pathophysiology of adiponectin and to discuss its potential in the treatment of insulin resistance and atherosclerosis.

PMID:
15046547
[PubMed - indexed for MEDLINE]
Free full text
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Institute of Physiology, Academy of Sciences of the Czech Republic, Prague
    Loading ...
    Write to the Help Desk