Science. 2004 Mar 26;303(5666):2019-22.

Envelope-constrained neutralization-sensitive HIV-1 after heterosexual transmission.

Derdeyn CA, Decker JM, Bibollet-Ruche F, Mokili JL, Muldoon M, Denham SA, Heil ML, Kasolo F, Musonda R, Hahn BH, Shaw GM, Korber BT, Allen S, Hunter E.

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Department of Microbiology, University of Alabama at Birmingham, Birmingham, AL 35294 USA.

Abstract

Heterosexual transmission accounts for the majority of human immunodeficiency virus-1 (HIV-1) infections worldwide, yet the viral properties that determine transmission fitness or outgrowth have not been elucidated. Here we show, for eight heterosexual transmission pairs, that recipient viruses were monophyletic, encoding compact, glycan-restricted envelope glycoproteins. These viruses were also uniquely sensitive to neutralization by antibody from the transmitting partner. Thus, the exposure of neutralizing epitopes, which are lost in chronic infection because of immune escape, appears to be favored in the newly infected host. This reveals characteristics of the envelope glycoprotein that influence HIV-1 transmission and may have implications for vaccine design.

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Science. 2004 Mar 26;303(5666):1956.

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Envelope-constrained neutralization-sensitive HIV-1 after heterosexual transmission.

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