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Fertil Steril. 2004 Mar;81(3):551-5.

Single blastocyst transfer: a prospective randomized trial.

Author information

  • 1Colorado Center for Reproductive Medicine, Englewood, Colorado 80110, USA. dgardner@colocrm.com

Abstract

OBJECTIVE:

To determine the efficacy of single blastocyst transfer.

DESIGN:

Prospective randomized trial.

SETTING:

Private assisted reproductive technology unit.

PATIENT(S):

Forty-eight women undergoing IVF-embryo transfer with day 3 FSH <or=10 mIU/mL and at least 10 follicles >12 mm in diameter on day of hCG administration.

INTERVENTION(S):

Embryo culture to the blastocyst stage in sequential media G1/G2 followed by transfer of either one or two blastocysts.

MAIN OUTCOME MEASURE(S):

Implantation rate, ongoing pregnancy rate, and twinning.

RESULT(S):

The transfer of a single blastocyst resulted in an implantation and ongoing pregnancy rate of 60.9% with no twins. The transfer of two blastocysts resulted in an implantation rate of 56%, an ongoing pregnancy rate of 76% with a 47.4% incidence of twins.

CONCLUSION(S):

Single blastocyst transfer is an effective method of eliminating multiple births while maintaining high pregnancy rates in this selected group of patients.

[PubMed - indexed for MEDLINE]
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