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Curr Opin Cell Biol. 2004 Feb;16(1):99-105.

Formin-induced nucleation of actin filaments.

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  • 1Biology Department, University of Pennsylvania, Philadelphia, PA 19104-6018, USA.


Formins are proteins best defined by the presence of the unique, highly conserved formin homology domain 2 (FH2). FH2 is necessary and sufficient to nucleate an actin filament in vitro. The FH2 domain also binds to the filament's barbed end, modulating its elongation and protecting it from capping proteins. FH2 itself appears to be a processive cap that walks with the barbed end as it elongates.

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