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Trends Microbiol. 2004 Feb;12(2):89-95.

The biology of Gram-positive sortase enzymes.

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  • 1Division of Infection and Immunity, The Institute of Biomedical and Life Sciences, University of Glasgow, Glasgow, Scotland, UK G12 8QQ.


Surface proteins of Gram-positive pathogens play various key roles in pathogenicity. Therefore, these proteins are of great interest in terms of understanding the infection process and have potential as targets for therapy. A major mechanism for the surface display of proteins by Gram-positive bacteria is sortase-mediated covalent attachment to the cell wall. The importance of sortase enzymes in the virulence of several pathogens is now becoming apparent, as are some of the more detailed workings of the enzyme and anchoring pathway. These recent advances are discussed.

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