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Curr Opin Microbiol. 2004 Feb;7(1):78-84.

Salmonella redirects phagosomal maturation.

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  • 1Infection, Immunity, Injury and Repair Program, The Hospital for Sick Children, 555 University Ave., Toronto, Ontario, M5G 1X8, Canada.


Following invasion of host cells, Salmonella occupies an intracellular vacuole that superficially resembles a phagosome. However, unlike bona fide phagosomes that undergo a maturation process to become microbicidal phago-lysosomes, Salmonella avoid killing by arresting and diverting the maturation program of the invasion vacuole. As a result of this re-routing, the bacteria generate a protected niche where they survive and replicate.

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