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Cell. 2004 Mar 19;116(6):769-78.

Socializing with the neighbors: stem cells and their niche.

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  • 1Howard Hughes Medical Institute, The Rockefeller University, New York, NY 10021, USA. fuchslb@rockefeller.edu

Abstract

The potential of stem cells in regenerative medicine relies upon removing them from their natural habitat, propagating them in culture, and placing them into a foreign tissue environment. To do so, it is essential to understand how stem cells interact with their microenvironment, the so-called stem cell niche, to establish and maintain their properties. In this review, we examine adult stem cell niches and their impact on stem cell biology.

PMID:
15035980
[PubMed - indexed for MEDLINE]
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