Ann Hum Genet. 1992 May;56(Pt 2):99-103.

Dominant genes for colorectal cancer are not rare.

Houlston RS, Collins A, Slack J, Morton NE.

Source

Department of Community Medicine, Southampton General Hospital.

Abstract

The genetic basis for colorectal cancer was investigated by complex segregation analysis of a published series of consecutive pedigrees ascertained through patients undergoing treatment for colorectal cancer. Analysis favoured a dominant gene or genes with a frequency of 0.006 with a lifetime penetrance of 0.63. These genes account for 81% of colorectal cancer in patients under 35, however, by 65 about 85% are phenocopies.

PMID:: 1503398; [PubMed - indexed for MEDLINE]

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Research Support, Non-U.S. Gov't

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Medical

Colorectal Cancer - MedlinePlus Health Information

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