Annu Rev Immunol. 2004;22:745-63.

Central memory and effector memory T cell subsets: function, generation, and maintenance.

Source

Institute for Research in Biomedicine, CH-6500 Bellinzona, Switzerland. federica.sallusto@irb.unisi.ch

Abstract

The memory T cell pool functions as a dynamic repository of antigen-experienced T lymphocytes that accumulate over the lifetime of the individual. Recent studies indicate that memory T lymphocytes contain distinct populations of central memory (TCM) and effector memory (TEM) cells characterized by distinct homing capacity and effector function. This review addresses the heterogeneity of TCM and TEM, their differentiation stages, and the current models for their generation and maintenance in humans and mice.

PMID:: 15032595; [PubMed - indexed for MEDLINE]

Publication Types, MeSH Terms

Publication Types

MeSH Terms

LinkOut - more resources

Full Text Sources

Other Literature Sources

Medical

ClinicalTrials.gov

Supplemental Content

Save items

Related citations in PubMed

Differential susceptibility of naïve, central memory and effector memory T cells to dendritic cell-mediated HIV-1 transmission. [Retrovirology. 2006]
Differential susceptibility of naïve, central memory and effector memory T cells to dendritic cell-mediated HIV-1 transmission.
Groot F, van Capel TM, Schuitemaker J, Berkhout B, de Jong EC. Retrovirology. 2006 Aug 17; 3:52. Epub 2006 Aug 17.
The role for monocyte chemoattractant protein-1 in the generation and function of memory CD8+ T cells. [J Immunol. 2008]
The role for monocyte chemoattractant protein-1 in the generation and function of memory CD8+ T cells.
Wang T, Dai H, Wan N, Moore Y, Dai Z. J Immunol. 2008 Mar 1; 180(5):2886-93.
Early simultaneous production of intranodal CD4 Th2 effectors and recirculating rapidly responding central-memory-like CD4 T cells. [Eur J Immunol. 2009]
Early simultaneous production of intranodal CD4 Th2 effectors and recirculating rapidly responding central-memory-like CD4 T cells.
Serre K, Mohr E, Toellner KM, Cunningham AF, Bird R, Khan M, MacLennan IC. Eur J Immunol. 2009 Jun; 39(6):1573-86.
Review Migration and differentiation of CD8+ T cells. [Immunol Rev. 2002]
Review Migration and differentiation of CD8+ T cells.
Weninger W, Manjunath N, von Andrian UH. Immunol Rev. 2002 Aug; 186:221-33.
Review Understanding the generation and function of memory T cell subsets. [Curr Opin Immunol. 2005]
Review Understanding the generation and function of memory T cell subsets.
Lanzavecchia A, Sallusto F. Curr Opin Immunol. 2005 Jun; 17(3):326-32.

See reviews... See all...

Cited by over 100 PubMed Central articles

Heterogeneity within T Cell Memory: Implications for Transplant Tolerance. [Front Immunol. 2012]
Heterogeneity within T Cell Memory: Implications for Transplant Tolerance.
Krummey SM, Ford ML. Front Immunol. 2012; 3:36. Epub 2012 Mar 1.
Regulation of Antigen-Experienced T Cells: Lessons from the Quintessential Memory Marker CD44. [Front Immunol. 2012]
Regulation of Antigen-Experienced T Cells: Lessons from the Quintessential Memory Marker CD44.
Baaten BJ, Tinoco R, Chen AT, Bradley LM. Front Immunol. 2012; 3:23. Epub 2012 Feb 27.
The ambiguity in immunology. [Front Immunol. 2012]
The ambiguity in immunology.
Barnaba V, Paroli M, Piconese S. Front Immunol. 2012; 3:18. Epub 2012 Feb 22.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Central memory and effector memory T cell subsets: function, generation, and mai...
Central memory and effector memory T cell subsets: function, generation, and maintenance.
Annu Rev Immunol. 2004 ;22:745-63.

PubMed
Breast cancer and environmental risks: where is the link?
Breast cancer and environmental risks: where is the link?
J Environ Health. 2004 Mar ;66(7):24-32, 40; quiz 41-2.

PubMed
[Highest level of division in the organism classification. 1. Prokaryotes and eu...
[Highest level of division in the organism classification. 1. Prokaryotes and eukaryotes].
Zh Obshch Biol. 2004 Jan-Feb ;65(1):19-38.

PubMed
Symptoms of ill health ascribed to electromagnetic field exposure--a questionnai...
Symptoms of ill health ascribed to electromagnetic field exposure--a questionnaire survey.
Int J Hyg Environ Health. 2004 Feb ;207(2):141-50.

PubMed
Medical complications experienced by a cohort of stroke survivors during inpatie...
Medical complications experienced by a cohort of stroke survivors during inpatient, tertiary-level stroke rehabilitation.
Arch Phys Med Rehabil. 2004 Mar ;85(3):466-9.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to: