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Microbiol Immunol. 2004;48(3):147-54.

Toll-like receptor 3: a link between toll-like receptor, interferon and viruses.

Author information

  • 1Department of Immunology, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, Japan. matsumoto-mi@mc.pref.osaka.jp

Abstract

Production of type I interferon (IFN-alpha/beta) by virus-infected cells is the central event in their antiviral immune responses. In mammalian cells, IFN-alpha/beta gene transcription is induced through distinct signaling pathways by viral infection or by treatment with double-stranded (ds) RNA, which is an intermediate of virus replication. Toll-like receptor 3 (TLR3) was found to recognize dsRNA and transmit signals to activate NF-kappaB and the IFN-beta promoter. Recent identification of the TLR3-adaptor protein and its downstream signaling molecules, which are involved in IFN-alpha/beta production, revealed a novel IFN-inducing pathway for an anti-viral immune response. Here, we summarize the current knowledge of TLR3-mediated immune responses.

PMID:
15031527
[PubMed - indexed for MEDLINE]
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