Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
Immunology. 2004 Feb;111(2):129-37.

CD4+ CD25+ Treg: divide and rule?

Author information

  • MRC Centre for Immune Regulation, University of Birmingham Medical School, Birmingham, UK. L.S.Walker@bham.ac.uk

Abstract

Research on CD4+ CD25+ regulatory T cells (Treg) has gathered momentum over the last five years but many aspects of their fundamental biology remain elusive. Treg have been considered to be 'naturally anergic' based on their failure to proliferate in response to T-cell receptor ligation in vitro. Several recent studies challenge this view and demonstrate a robust proliferative capacity for CD25+ cells. The significance of this finding for Treg homeostasis and function is considered below.

PMID:
15027897
[PubMed - indexed for MEDLINE]
PMCID:
PMC1782405
Free PMC Article

Images from this publication.See all images (4)Free text

Figure 1
Figure 2
Figure 3
Figure 4
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Icon for Blackwell Publishing Icon for PubMed Central
    Loading ...
    Write to the Help Desk