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Blood. 2004 Jul 1;104(1):26-33. Epub 2004 Mar 16.

Antigen-induced regulatory T cells.

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  • 1Center for Cell and Gene Therapy and Department of Pediatrics, Baylor College of Medicine, and Texas Children's Hospital, Houston, 77030, USA. sxvigour@txccc.org


Regulatory T cells participate in immunologic homeostasis by active suppression of inappropriate immune responses. Regulatory T lymphocytes expressing CD4 and CD25 antigens and naturally present in the peripheral blood were the first to be phenotypically characterized. However, their small number and antigen nonspecific suppression has prompted efforts to identify and dissect antigen-specific regulatory T cells. In this review we discuss how antigen-specific regulatory T cells can be identified, the cellular and molecular mechanisms underlying their induction and activity, and the challenges facing their potential clinical application.

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