Send to:

Choose Destination
See comment in PubMed Commons below
Pharmacol Res. 2004 Jun;49(6):503-8.

Endothelium-dependent hyperpolarizations: the history.

Author information

  • 1Department of Pharmacology, University of Hong Kong, Hong Kong.


Endothelial cells control the tone and the growth of the underlying vascular smooth muscle by releasing Nitric Oxide (NO). This introduction summarizes the early experiments which first suggested and then demonstrated the existence of an alternative pathway, endothelium-dependent hyperpolarization. It reviews why endothelium-derived hyperpolarizing factor (EDHF) is not likely to be either NO or prostacyclin. It sets the stage for the other contributions of this special issue devoted to EDHF that will discuss in depth the current knowledge concerning endothelium-dependent hyperpolarizations.

[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Write to the Help Desk