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Biologicals. 2004 Mar;32(1):57-60.

Mitogenic activity of Cratylia mollis lectin on human lymphocytes.

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  • 1Universidade Federal de Pernambuco, Centro de Ciências Biológicas (CCB), Departamento de Bioquímica, Rua Prof. Nelson Chaves S/N, 50670-901 Cidade Universitária Recife-PE, Brazil.


The mitogenic effect of Cratylia mollis seed lectin preparations containing two (Cramoll 1,4) or one molecular form (Cramoll 1) showed activity similar to the well known T-cell mitogen, concanavalin A (Con A). The effect on human lymphocytes was analyzed through a colorimetric assay using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT). Inhibition of lymphocyte proliferation with methyl-alpha-d-mannoside (both preparations) indicated that the mitogenic effect involved carbohydrate lectin binding sites.

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