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Curr Opin Immunol. 2004 Apr;16(2):246-50.

Regulation of B-cell development by antibody specificity.

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  • 1Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-7290, USA.


Although autoantigen-induced negative selection plays an important role in shaping the mature B-cell repertoire, studies in recent years have suggested that differentiation into any of the three mature B-cell subsets (marginal zone B cells, follicular B cells and B-1 B cells) is not a passive product of autoreactive B-cell elimination. Instead, evidence suggests that entry into a mature subset involves active B-cell receptor signaling and self-antigen-mediated positive selection.

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