Wnt inhibitory factor-1: a candidate for a new player in tumorigenesis of intestinal epithelial cells

Cancer Lett. 2004 Mar 31;206(1):107-13. doi: 10.1016/j.canlet.2003.10.024.

Abstract

Using cDNA-Representational Difference Analysis it was found that expression of Opg, Ctse, Krt2-4, Fut-2, 24p3 and Wif-1 genes was elevated in intestinal adenomas as compared to normal epithelial cells of Apc(Min/+) mutant mice. Expression of Wif-1, which encodes Wnt inhibitory factor-1 was also detected in a number of tumor cell lines of epithelial cell origin including two human colon adenocarcinoma cell lines. The possible role of Wif-1 over-expression in the etiology of colorectal cancer is discussed.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adaptor Proteins, Signal Transducing
  • Adenocarcinoma / metabolism
  • Adenocarcinoma / pathology
  • Adenoma / metabolism
  • Adenoma / pathology
  • Adenomatous Polyposis Coli Protein / genetics
  • Adenomatous Polyposis Coli Protein / physiology*
  • Animals
  • Biomarkers, Tumor / genetics
  • Biomarkers, Tumor / metabolism
  • Carrier Proteins / metabolism*
  • Cell Transformation, Neoplastic*
  • Colorectal Neoplasms / metabolism
  • Colorectal Neoplasms / pathology
  • DNA, Complementary / genetics
  • Epithelial Cells / metabolism
  • Epithelial Cells / pathology*
  • Extracellular Matrix Proteins
  • Gene Expression Regulation, Neoplastic
  • Humans
  • Intercellular Signaling Peptides and Proteins
  • Intestinal Mucosa / metabolism
  • Intestinal Neoplasms / metabolism
  • Intestinal Neoplasms / pathology*
  • Intestines / pathology*
  • Intracellular Signaling Peptides and Proteins
  • Mice
  • Mice, Inbred C57BL
  • Mice, Knockout
  • Neoplasm Proteins / genetics
  • Neoplasm Proteins / metabolism
  • RNA, Messenger / genetics
  • RNA, Messenger / metabolism
  • Repressor Proteins / metabolism*
  • Reverse Transcriptase Polymerase Chain Reaction
  • Tumor Cells, Cultured

Substances

  • Adaptor Proteins, Signal Transducing
  • Adenomatous Polyposis Coli Protein
  • Biomarkers, Tumor
  • Carrier Proteins
  • DNA, Complementary
  • Extracellular Matrix Proteins
  • Intercellular Signaling Peptides and Proteins
  • Intracellular Signaling Peptides and Proteins
  • Neoplasm Proteins
  • RNA, Messenger
  • Repressor Proteins
  • WIF1 protein, human
  • Wif1 protein, mouse